An SH2-domain-containing kinase negatively regulates the phosphatidylinositol-3 kinase pathway

SHK1 is a novel dual-specificity kinase that contains an SH2 domain in its C-terminal region. We demonstrate that SHK1 is required for proper chemotaxis and phagocytosis. Mutant shk1 null cells lack polarity, move very slowly, and exhibit an elevated and temporally extended chemoattractant-mediated...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Genes Dev
Main Authors: Moniakis, John, Funamoto, Satoru, Fukuzawa, Masashi, Meisenhelder, Jill, Araki, Tsuyoshi, Abe, Tomoaki, Meili, Ruedi, Hunter, Tony, Williams, Jeffrey, Firtel, Richard A.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2001
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312652/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11274054/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.871001
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker