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An SH2-domain-containing kinase negatively regulates the phosphatidylinositol-3 kinase pathway
SHK1 is a novel dual-specificity kinase that contains an SH2 domain in its C-terminal region. We demonstrate that SHK1 is required for proper chemotaxis and phagocytosis. Mutant shk1 null cells lack polarity, move very slowly, and exhibit an elevated and temporally extended chemoattractant-mediated...
Shranjeno v:
| izdano v: | Genes Dev |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cold Spring Harbor Laboratory Press
2001
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312652/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11274054/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.871001 |
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