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A completely transformation-defective point mutant of polyomavirus middle T antigen which retains full associated phosphatidylinositol kinase activity.

By using a random mutagenesis procedure combined with a recombinant retrovirus vector, mutants of polyomavirus middle T antigen (MTAg) were generated. Three new MTAg mutants with various degrees of transformation competence were more thoroughly characterized. All of the mutants produced a stable MTA...

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Bibliografiske detaljer
Main Authors: Druker, B J, Ling, L E, Cohen, B, Roberts, T M, Schaffhausen, B S
Format: Artigo
Sprog:Inglês
Udgivet: 1990
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC247915/
https://ncbi.nlm.nih.gov/pubmed/2166824
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