A completely transformation-defective point mutant of polyomavirus middle T antigen which retains full associated phosphatidylinositol kinase activity.

By using a random mutagenesis procedure combined with a recombinant retrovirus vector, mutants of polyomavirus middle T antigen (MTAg) were generated. Three new MTAg mutants with various degrees of transformation competence were more thoroughly characterized. All of the mutants produced a stable MTA...

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Pubblicato in:	J Virol
Autori principali:	Druker, B J, Ling, L E, Cohen, B, Roberts, T M, Schaffhausen, B S
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC247915/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2166824/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.64.9.4454-4461.1990
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