An SH2-domain-containing kinase negatively regulates the phosphatidylinositol-3 kinase pathway

SHK1 is a novel dual-specificity kinase that contains an SH2 domain in its C-terminal region. We demonstrate that SHK1 is required for proper chemotaxis and phagocytosis. Mutant shk1 null cells lack polarity, move very slowly, and exhibit an elevated and temporally extended chemoattractant-mediated...

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Autori principali: Moniakis, John, Funamoto, Satoru, Fukuzawa, Masashi, Meisenhelder, Jill, Araki, Tsuyoshi, Abe, Tomoaki, Meili, Ruedi, Hunter, Tony, Williams, Jeffrey, Firtel, Richard A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2001
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC312652/
https://ncbi.nlm.nih.gov/pubmed/11274054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.871001
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