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Predict impact of single amino acid change upon protein structure

BACKGROUND: Amino acid point mutations (nsSNPs) may change protein structure and function. However, no method directly predicts the impact of mutations on structure. Here, we compare pairs of pentamers (five consecutive residues) that locally change protein three-dimensional structure (3D, RMSD>0...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Schaefer, Christian, Rost, Burkhard
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395892/
https://ncbi.nlm.nih.gov/pubmed/22759652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-13-S4-S4
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