The Genetics of PTPN1 and Obesity: Insights from Mouse Models of Tissue-Specific PTP1B Deficiency

The protein tyrosine phosphatase PTP1B is a negative regulator of both insulin and leptin signaling and is involved in the control of glucose homeostasis and energy expenditure. Due to its prominent role in regulating metabolism, PTP1B is a promising therapeutic target for the treatment of human obe...

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Bibliographic Details
Main Authors: Tsou, Ryan C., Bence, Kendra K.
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2012
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395189/
https://ncbi.nlm.nih.gov/pubmed/22811891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/926857
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