A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis

Sepsis is a deadly disease characterized by the inability to regulate the inflammatory–coagulation response in which the endothelium plays a key role. The cause of this perturbation remains poorly understood and has hampered the development of effective therapeutics. Matrix metalloproteases (MMPs) a...

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Bibliographische Detailangaben
Hauptverfasser: Tressel, Sarah L, Kaneider, Nicole C, Kasuda, Shogo, Foley, Caitlin, Koukos, Georgios, Austin, Karyn, Agarwal, Anika, Covic, Lidija, Opal, Steven M, Kuliopulos, Athan
Format: Artigo
Sprache:Inglês
Veröffentlicht: WILEY-VCH Verlag 2011
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3394510/
https://ncbi.nlm.nih.gov/pubmed/21591259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201100145
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