p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium

Senescence has been implicated as an important mechanism of tumour suppression in a number of human malignancies, including colorectal cancer (CRC). However, we still have a relatively poor understanding of how the underlying mutations that occur in cancer cause senescence and its relevance in vivo....

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Autors principals: Cole, Alicia M, Ridgway, Rachel A, Derkits, Sahra E, Parry, Lee, Barker, Nick, Clevers, Hans, Clarke, Alan R, Sansom, Owen J
Format: Artigo
Idioma:Inglês
Publicat: WILEY-VCH Verlag 2010
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3394507/
https://ncbi.nlm.nih.gov/pubmed/20976827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201000101
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