Cyclin D2-CDK4/6 is required for efficient proliferation and tumorigenesis following Apc loss

Inactivation of the Apc gene is recognized as the key early event in the development of sporadic colorectal cancer where its loss leads to constitutive activation of β-catenin/TCF4 signaling and hence transcription of Wnt target genes such as c-Myc. Our and others previous studies have shown that al...

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Detalhes bibliográficos
Main Authors: Cole, AM, Myant, K, Reed, KR, Ridgway, RA, Athineos, D, Van den Brink, GR, Muncan, V, Clevers, H, Clarke, AR, Sicinski, P, Sansom, OJ
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974087/
https://ncbi.nlm.nih.gov/pubmed/20736363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0315
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