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Homology Modeling and Molecular Dynamics Simulations of the Active State of the Nociceptin Receptor (NOP) Reveals New Insights Into Agonist Binding And Activation

The opioid receptor-like receptor ORL1, also known as the nociceptin receptor (NOP), is a Class A GPCR in the opioid receptor family. Although NOP shares a significant homology with the other opioid receptors, it does not bind known opioid ligands and has been shown to have a distinct mechanism of a...

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Hlavní autoři: Daga, Pankaj R., Zaveri, Nurulain T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393802/
https://ncbi.nlm.nih.gov/pubmed/22489047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24077
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