Mouse-Adapted H9N2 Influenza A Virus PB2 Protein M147L and E627K Mutations Are Critical for High Virulence

H9N2 influenza viruses have been circulating worldwide in multiple avian species and have repeatedly infected humans to cause typical disease. The continued avian-to-human interspecies transmission of H9N2 viruses raises concerns about the possibility of viral adaption with increased virulence for h...

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Bibliografiske detaljer
Main Authors: Wang, Jingjing, Sun, Yipeng, Xu, Qi, Tan, Yuanyuan, Pu, Juan, Yang, Hanchun, Brown, Earl G., Liu, Jinhua
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393695/
https://ncbi.nlm.nih.gov/pubmed/22808250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040752
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