Virulence Determinants in the PB2 Gene of a Mouse-Adapted H9N2 Virus

The molecular bases of adaptation and pathogenicity of H9N2 influenza virus in mammals are largely unknown. Here, we show that a mouse-adapted PB2 gene with a phenylalanine-to-leucine mutation (F404L) mainly contributes to enhanced polymerase activity, replication, and pathogenicity of H9N2 in mice...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Liu, Qingtao, Huang, Junqing, Chen, Yuxin, Chen, Hongzhi, Li, Qunhui, He, Liang, Hao, Xiaoli, Liu, Jingjing, Gu, Min, Hu, Jiao, Wang, Xiaoquan, Hu, Shunlin, Liu, Xiaowen, Liu, Xiufan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301167/
https://ncbi.nlm.nih.gov/pubmed/25339773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01775-14
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