PA-X Decreases the Pathogenicity of Highly Pathogenic H5N1 Influenza A Virus in Avian Species by Inhibiting Virus Replication and Host Response

PA-X is a newly discovered protein that decreases the virulence of the 1918 H1N1 virus in a mouse model. However, the role of PA-X in the pathogenesis of highly pathogenic avian influenza viruses (HPAIV) of the H5N1 subtype in avian species is totally unknown. By generating two PA-X-deficient viruse...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Hu, Jiao, Mo, Yiqun, Wang, Xiaoquan, Gu, Min, Hu, Zenglei, Zhong, Lei, Wu, Qiwen, Hao, Xiaoli, Hu, Shunlin, Liu, Wenbo, Liu, Huimou, Liu, Xiaowen, Liu, Xiufan
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2015
Assuntos:
Pathogenesis and Immunity
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4442343/
https://ncbi.nlm.nih.gov/pubmed/25631083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02132-14
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