The PA-Gene-Mediated Lethal Dissemination and Excessive Innate Immune Response Contribute to the High Virulence of H5N1 Avian Influenza Virus in Mice

Highly pathogenic H5N1 influenza A virus remains a substantial threat to public health. To understand the molecular basis and host mechanism for the high virulence of H5N1 viruses in mammals, we compared two H5N1 isolates which have similar genetic backgrounds but greatly differ in their virulence i...

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Detalhes bibliográficos
Main Authors: Hu, Jiao, Hu, Zenglei, Song, Qingqing, Gu, Min, Liu, Xiaowen, Wang, Xiaoquan, Hu, Shunlin, Chen, Chaoyang, Liu, Huimou, Liu, Wenbo, Chen, Sujuan, Peng, Daxin, Liu, Xiufan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571398/
https://ncbi.nlm.nih.gov/pubmed/23255810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02891-12
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