The PA-Gene-Mediated Lethal Dissemination and Excessive Innate Immune Response Contribute to the High Virulence of H5N1 Avian Influenza Virus in Mice

Highly pathogenic H5N1 influenza A virus remains a substantial threat to public health. To understand the molecular basis and host mechanism for the high virulence of H5N1 viruses in mammals, we compared two H5N1 isolates which have similar genetic backgrounds but greatly differ in their virulence i...

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Bibliografski detalji
Glavni autori: Hu, Jiao, Hu, Zenglei, Song, Qingqing, Gu, Min, Liu, Xiaowen, Wang, Xiaoquan, Hu, Shunlin, Chen, Chaoyang, Liu, Huimou, Liu, Wenbo, Chen, Sujuan, Peng, Daxin, Liu, Xiufan
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2013
Teme:
Pathogenesis and Immunity
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571398/
https://ncbi.nlm.nih.gov/pubmed/23255810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02891-12
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