The PA-Gene-Mediated Lethal Dissemination and Excessive Innate Immune Response Contribute to the High Virulence of H5N1 Avian Influenza Virus in Mice

Highly pathogenic H5N1 influenza A virus remains a substantial threat to public health. To understand the molecular basis and host mechanism for the high virulence of H5N1 viruses in mammals, we compared two H5N1 isolates which have similar genetic backgrounds but greatly differ in their virulence i...

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Hlavní autoři: Hu, Jiao, Hu, Zenglei, Song, Qingqing, Gu, Min, Liu, Xiaowen, Wang, Xiaoquan, Hu, Shunlin, Chen, Chaoyang, Liu, Huimou, Liu, Wenbo, Chen, Sujuan, Peng, Daxin, Liu, Xiufan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571398/
https://ncbi.nlm.nih.gov/pubmed/23255810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02891-12
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