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Influenza virus adaptation PB2-627K modulates nucleocapsid inhibition by the pathogen sensor RIG-I
The cytoplasmic RNA helicase RIG-I mediates innate sensing of RNA viruses. The genomes of influenza A virus (FLUAV) are encapsidated by the nucleoprotein and associated with RNA polymerase, posing potential barriers to RIG-I sensing. We show that RIG-I recognizes the 5’-triphosphorylated dsRNA on FL...
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| Veröffentlicht in: | Cell Host Microbe |
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| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4359673/ https://ncbi.nlm.nih.gov/pubmed/25704008 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2015.01.005 |
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