Influenza virus adaptation PB2-627K modulates nucleocapsid inhibition by the pathogen sensor RIG-I

The cytoplasmic RNA helicase RIG-I mediates innate sensing of RNA viruses. The genomes of influenza A virus (FLUAV) are encapsidated by the nucleoprotein and associated with RNA polymerase, posing potential barriers to RIG-I sensing. We show that RIG-I recognizes the 5’-triphosphorylated dsRNA on FL...

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Publicado no:Cell Host Microbe
Main Authors: Weber, Michaela, Sediri, Hanna, Felgenhauer, Ulrike, Binzen, Ina, Bänfer, Sebastian, Jacob, Ralf, Brunotte, Linda, García-Sastre, Adolfo, Schmid-Burgk, Jonathan L., Schmidt, Tobias, Hornung, Veit, Kochs, Georg, Schwemmle, Martin, Klenk, Hans-Dieter, Weber, Friedemann
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359673/
https://ncbi.nlm.nih.gov/pubmed/25704008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2015.01.005
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