Reversion of PB2-627E to -627K during Replication of an H5N1 Clade 2.2 Virus in Mammalian Hosts Depends on the Origin of the Nucleoprotein

H5N1 highly pathogenic avian influenza viruses (HPAIV) of clade 2.2 spread from Southeast Asia to Europe. Intriguingly, in contrast to all common avian strains specifying glutamic acid at position 627 of the PB2 protein (PB2-627E), they carry a lysine at this position (PB2-627K), which is normally f...

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Detalhes bibliográficos
Main Authors: Bogs, Jessica, Kalthoff, Donata, Veits, Jutta, Pavlova, Sophia, Schwemmle, Martin, Mänz, Benjamin, Mettenleiter, Thomas C., Stech, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187502/
https://ncbi.nlm.nih.gov/pubmed/21849466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00786-11
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