Incoming RNA virus nucleocapsids containing a 5′-triphosphorylated genome activate RIG-I and anti-viral signaling

Host defense to RNA viruses depends on rapid intracellular recognition of viral RNA by two cytoplasmic RNA helicases, RIG-I and MDA5. RNA transfection experiments indicate that RIG-I responds to naked double-stranded (ds) RNAs with a triphosphorylated 5′ (5′ppp) terminus. However, identity of the RI...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Cell Host Microbe
Autores principales: Weber, Michaela, Gawanbacht, Ali, Habjan, Matthias, Rang, Andreas, Borner, Christoph, Schmidt, Anna Mareike, Veitinger, Sophie, Jacob, Ralf, Devignot, Stéphanie, Kochs, Georg, García-Sastre, Adolfo, Weber, Friedemann
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5515363/
https://ncbi.nlm.nih.gov/pubmed/23498958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2013.01.012
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares