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Dissecting the Urokinase Activation Pathway Using Urokinase-Activated Anthrax Toxin

Anthrax toxin is a three-part toxin secreted by Bacillus anthracis, consisting of protective antigen (PrAg), edema factor (EF), and lethal factor (LF). To intoxicate host mammalian cells, PrAg, the cell-binding moiety of the toxin, binds to cells and is then proteolytically activated by furin on the...

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Main Authors: Liu, Shihui, Bugge, Thomas H., Frankel, Arthur E., Leppla, Stephen H.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393601/
https://ncbi.nlm.nih.gov/pubmed/19377974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-60327-003-8_10
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