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Potent antitumor activity of a urokinase-activated engineered anthrax toxin

The acquisition of cell-surface urokinase plasminogen activator activity is a hallmark of malignancy. We generated an engineered anthrax toxin that is activated by cell-surface urokinase in vivo and displays limited toxicity to normal tissue but broad and potent tumoricidal activity. Native anthrax...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Liu, Shihui, Aaronson, Hannah, Mitola, David J., Leppla, Stephen H., Bugge, Thomas H.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: The National Academy of Sciences 2003
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC141052/
https://ncbi.nlm.nih.gov/pubmed/12525700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0236849100
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