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Potent antitumor activity of a urokinase-activated engineered anthrax toxin
The acquisition of cell-surface urokinase plasminogen activator activity is a hallmark of malignancy. We generated an engineered anthrax toxin that is activated by cell-surface urokinase in vivo and displays limited toxicity to normal tissue but broad and potent tumoricidal activity. Native anthrax...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The National Academy of Sciences
2003
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC141052/ https://ncbi.nlm.nih.gov/pubmed/12525700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0236849100 |
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