A Single Amino Acid at the Hemagglutinin Cleavage Site Contributes to the Pathogenicity and Neurovirulence of H5N1 Influenza Virus in Mice

H5 influenza viruses containing a motif of multiple basic amino acids at the hemagglutinin (HA) cleavage site (HACS) are highly pathogenic in chicken but display different virulence phenotypes in mammals. Previous studies have shown that multiple basic amino acids of H5N1 influenza virus are a prere...

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Detalhes bibliográficos
Main Authors: Zhang, Yi, Sun, Yipeng, Sun, Honglei, Pu, Juan, Bi, Yuhai, Shi, Yi, Lu, Xishan, Li, Jing, Zhu, Qingyu, Gao, George F., Yang, Hanchun, Liu, Jinhua
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393526/
https://ncbi.nlm.nih.gov/pubmed/22496231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.07142-11
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