Antiviral Effects of Small Interfering RNA Simultaneously Inducing RNA Interference and Type 1 Interferon in Coxsackievirus Myocarditis

Antiviral therapeutics are currently unavailable for treatment of coxsackievirus B3, which can cause life-threatening myocarditis. A modified small interfering RNA (siRNA) containing 5′-triphosphate, 3p-siRNA, was shown to induce RNA interference and interferon activation. We aimed to develop a pote...

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Bibliographic Details
Main Authors: Ahn, Jeonghyun, Ko, Ara, Jun, Eun Jung, Won, Minah, Kim, Yoo Kyum, Ju, Eun-Seon, Jeon, Eun Seok, Lee, Heuiran
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393429/
https://ncbi.nlm.nih.gov/pubmed/22508300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06050-12
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