A Small Interfering RNA Targeting Coxsackievirus B3 Protects Permissive HeLa Cells from Viral Challenge

We examined the ability of small interfering RNAs (siRNAs) to disrupt infection by coxsackievirus B3 (CVB3). The incorporation of siRNAs dramatically decreased cell death in permissive HeLa cells in parallel with a reduction in viral replication. Three of four siRNAs had potent anti-CVB3 activity. T...

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Detalhes bibliográficos
Main Authors: Ahn, Jeonghyun, Jun, Eun Seok, Lee, Hui Sun, Yoon, Seung Yong, Kim, DongHou, Joo, Chul-Hyun, Kim, Yoo Kyum, Lee, Heuiran
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1143761/
https://ncbi.nlm.nih.gov/pubmed/15956603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.13.8620-8624.2005
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