Modeling Approach To Characterize Intraocular Doripenem Pharmacokinetics after Intravenous Administration to Rabbits, with Tentative Extrapolation to Humans

The aim of this study was to determine the penetration of doripenem administered intravenously into the rabbit aqueous and vitreous humors. Nineteen New Zealand White rabbits received a 20-mg dose of doripenem intravenously over 60 min. Specimens of aqueous humor, vitreous humor, and blood were obta...

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Egile Nagusiak: Semoun, Oudy, Marchand, Sandrine, Grégoire, Nicolas, Lamarche, Isabelle, Adier, Christophe, Laroche, Laurent, Goldschmidt, Pablo, Couet, William
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2012
Gaiak:
Pharmacology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393392/
https://ncbi.nlm.nih.gov/pubmed/22526310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06329-11
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