Myofilament Ca sensitization increases cytosolic Ca binding affinity, alters intracellular Ca homeostasis and causes pause-dependent Ca triggered arrhythmia

RATIONALE: Ca binding to the troponin complex represents a major portion of cytosolic Ca buffering. Troponin mutations that increase myofilament Ca sensitivity are associated with familial hypertrophic cardiomyopathy and confer a high risk for sudden death. In mice, Ca sensitization causes ventricul...

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Autori principali: Schober, Tilmann, Huke, Sabine, Venkataraman, Raghav, Gryshchenko, Oleksiy, Kryshtal, Dmytro, Hwang, Hyun-Seok, Baudenbacher, Franz J., Knollmann, Björn C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393041/
https://ncbi.nlm.nih.gov/pubmed/22647877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.112.270041
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