Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells

Presenilin (PSEN) deficiency is accompanied by accumulation of endosomes and autophagosomes, likely caused by impaired endo-lysosomal fusion. Recently, Lee et al. (2010. Cell. doi: http://dx.doi.org/10.1016/j.cell.2010.05.008) attributed this phenomenon to PSEN1 enabling the transport of mature V0a1...

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Detalhes bibliográficos
Main Authors: Coen, Katrijn, Flannagan, Ronald S., Baron, Szilvia, Carraro-Lacroix, Luciene R., Wang, Dong, Vermeire, Wendy, Michiels, Christine, Munck, Sebastian, Baert, Veerle, Sugita, Shuzo, Wuytack, Frank, Hiesinger, Peter Robin, Grinstein, Sergio, Annaert, Wim
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392942/
https://ncbi.nlm.nih.gov/pubmed/22753898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201201076
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