Duplex Interrogation by a Direct DNA Repair Protein in Search of Base Damage

ALKBH2 is a direct DNA repair dioxygenase guarding mammalian genome against N(1)-methyladenine, N(3)-methylcytosine, and 1,N(6)-ethenoadenine damage. A prerequisite for repair is to identify these lesions in the genome. Here we present crystal structures of ALKBH2 bound to different duplex DNAs. Tog...

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Detalhes bibliográficos
Main Authors: Yi, Chengqi, Chen, Baoen, Qi, Bo, Zhang, Wen, Jia, Guifang, Zhang, Liang, Li, Charles J., Dinner, Aaron R., Yang, Cai-Guang, He, Chuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392526/
https://ncbi.nlm.nih.gov/pubmed/22659876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2320
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