Duplex Interrogation by a Direct DNA Repair Protein in Search of Base Damage

ALKBH2 is a direct DNA repair dioxygenase guarding mammalian genome against N(1)-methyladenine, N(3)-methylcytosine, and 1,N(6)-ethenoadenine damage. A prerequisite for repair is to identify these lesions in the genome. Here we present crystal structures of ALKBH2 bound to different duplex DNAs. Tog...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yi, Chengqi, Chen, Baoen, Qi, Bo, Zhang, Wen, Jia, Guifang, Zhang, Liang, Li, Charles J., Dinner, Aaron R., Yang, Cai-Guang, He, Chuan
Format:	Artigo
Language:	Inglês
Published:	2012
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3392526/ https://ncbi.nlm.nih.gov/pubmed/22659876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2320
Tags:	Add Tag No Tags, Be the first to tag this record!

Duplex Interrogation by a Direct DNA Repair Protein in Search of Base Damage

Similar Items