Structural biology of the Mre11:Nbs1 complex structure yields insights into ataxia–telangiectasia–like disease mutations and DNA damage signaling

The Mre11–Rad50–Nbs1 (MRN) complex tethers, processes and signals DNA double strand breaks, promoting genomic stability. To understand the functional architecture of MRN, we determined the crystal structures of the Schizosaccharomyces pombe Mre11 dimeric catalytic domain alone and in complex with a...

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Detalhes bibliográficos
Main Authors: Schiller, Christian B., Lammens, Katja, Guerini, Ilaria, Coordes, Britta, Feldmann, Heidi, Schlauderer, Florian, Möckel, Carolin, Schele, Alexandra, Sträβer, Katja, Jackson, Stephen P., Hopfner, Karl–Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392456/
https://ncbi.nlm.nih.gov/pubmed/22705791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2323
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