The Mre11:Rad50 structure shows an ATP dependent molecular clamp in DNA double-strand break repair

The MR (Mre11 nuclease and Rad50 ABC ATPase) complex is an evolutionarily conserved sensor for DNA double-strand breaks, highly genotoxic lesions linked to cancer development. MR can recognize and process DNA ends even if they are blocked and misfolded. To reveal its mechanism, we determined the cry...

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Main Authors: Lammens, Katja, Bemeleit, Derk J., Möckel, Carolin, Clausing, Emanuel, Schele, Alexandra, Hartung, Sophia, Schiller, Christian B., Lucas, Maria, Angermüller, Christof, Söding, Johannes, Sträßer, Katja, Hopfner, Karl-Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071652/
https://ncbi.nlm.nih.gov/pubmed/21458667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.02.038
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