The Mre11:Rad50 structure shows an ATP dependent molecular clamp in DNA double-strand break repair

The MR (Mre11 nuclease and Rad50 ABC ATPase) complex is an evolutionarily conserved sensor for DNA double-strand breaks, highly genotoxic lesions linked to cancer development. MR can recognize and process DNA ends even if they are blocked and misfolded. To reveal its mechanism, we determined the cry...

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Hauptverfasser: Lammens, Katja, Bemeleit, Derk J., Möckel, Carolin, Clausing, Emanuel, Schele, Alexandra, Hartung, Sophia, Schiller, Christian B., Lucas, Maria, Angermüller, Christof, Söding, Johannes, Sträßer, Katja, Hopfner, Karl-Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071652/
https://ncbi.nlm.nih.gov/pubmed/21458667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.02.038
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