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NMR and crystalstructures of the Pyrococcus horikoshii RadA intein guide a strategy for engineering a highly efficient and promiscuous intein

In protein splicing, an intervening protein sequence (intein) in the host protein excises itself out and ligates two split host protein sequences (exteins) to produce a mature host protein. Inteins require the involvement for the splicing of the first residue of the exteinthat follows the intein (wh...

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Bibliographic Details
Main Authors: Oeemig, Jesper S., Zhou, Dongwen, Kajander, Tommi, Wlodawer, Alexander, Iwaï, Hideo
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392434/
https://ncbi.nlm.nih.gov/pubmed/22560994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.04.029
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