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A proteasome inhibitor fails to attenuate dystrophic pathology in mdx mice
Dystrophin deficiency leads to increased proteasome activity in skeletal muscle. Previous observations suggest short-term inhibition of the proteasome restores dystrophin expression. Contrary to our hypothesis, eight days of MG-132 administration to mdx mice increased susceptibility to contraction i...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3392143/ https://ncbi.nlm.nih.gov/pubmed/22866241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/4f84a944d8930 |
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