Impact of oncogenic driver mutations on feedback between the PI3K and MEK pathways in cancer cells

Inhibition of the PI3K (phosphoinositide 3-kinase)/Akt/mTORC1 (mammalian target of rapamycin complex 1) and Ras/MEK [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase]/ERK pathways for cancer therapy has been pursued for over a decade with limited success. Em...

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Hlavní autoři: Yuen, Hiu-Fung, Abramczyk, Olga, Montgomery, Grant, Chan, Ka-Kui, Huang, Yu-Han, Sasazuki, Takehiko, Shirasawa, Senji, Gopesh, Srivastava, Chan, Kwok-Wah, Fennell, Dean, Janne, Pasi, El-Tanani, Mohamed, Murray, James T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2012
Témata:
Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392104/
https://ncbi.nlm.nih.gov/pubmed/22668349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20120050
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