Ran is a potential therapeutic target for cancer cells with molecular changes associated with activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways

PURPOSE: Cancer cells have been shown to be more susceptible to Ran knockdown compared to normal cells. We now investigate whether Ran is a potential therapeutic target of cancers with frequently found mutations that lead to higher Ras/MEK/ERK and PI3K/Akt/mTORC1 activities. EXPERIMENTAL DESIGN: Apo...

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Main Authors: Yuen, Hiu-Fung, Chan, Ka-Kui, Grills, Claire, Murray, James T., Platt-Higgins, Angela, Eldin, Osama Sharaf, O’Byrne, Ken, Janne, Pasi, Fennell, Dean A., Johnston, Patrick G., Rudland, Philip S., El-Tanani, Mohamed
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272446/
https://ncbi.nlm.nih.gov/pubmed/22090358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-2035
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