A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency

The molecular pathways leading from genomic instability to cellular senescence and/or cell death remain incompletely characterized. Using mouse embryonic fibroblasts with constitutively increased DNA damage due to the absence of the full-length form of the tumor suppressor Brca1 (Brca1(Δ11/ Δ11)), w...

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Hauptverfasser: Cao, Liu, Xu, Xioaling, Bunting, Samuel F., Liu, Jie, Wang, Rui-Hong, Cao, Longyue L., Wu, J. Julie, Peng, Tie-Nan, Chen, Junjie, Nussenzweig, Andre, Deng, Chu-Xia, Finkel, Toren
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392030/
https://ncbi.nlm.nih.gov/pubmed/19716796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.06.037
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