A carregar...
53BP1 loss rescues embryonic lethality but not genomic instability of BRCA1 total knockout mice
BRCA1 is critical for DNA double-strand break (DSB) repair by homologous recombination (HR). BRCA1 deficient mice are embryonic lethal. Previous studies have shown that 53BP1 knockout (KO) rescues embryonic lethality of BRCA1 hypomorphic mutant mice by restoring HR. Here, we show that 53BP1 KO can p...
Na minha lista:
| Publicado no: | Cell Death Differ |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7429965/ https://ncbi.nlm.nih.gov/pubmed/32139898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0521-4 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|