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Structural and functional characterization of H2 haplotype MAPT promoter: Unique neurospecific domains and a hypoxia–inducible element would enhance rationally targeted tauopathy research for Alzheimer’s disease
Alzheimer’s disease (AD) is the leading cause of dementia in the elderly. Extraneuronal plaque consisting primarily of amyloid β peptide and intraneuronal tangles of hyperphosphorylated microtubule–associated τ protein (τ, gene MAPT) are typical of AD. Misfolded τ is also implicated in Parkinson’s d...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3391566/ https://ncbi.nlm.nih.gov/pubmed/22310385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2012.01.049 |
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