Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levels

INTRODUCTION: MAPT encodes for tau, the predominant component of neurofibrillary tangles that are neuropathological hallmarks of Alzheimer’s disease (AD). Genetic association of MAPT variants with late-onset AD (LOAD) risk has been inconsistent, although insufficient power and incomplete assessment...

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Main Authors: Allen, Mariet, Kachadoorian, Michaela, Quicksall, Zachary, Zou, Fanggeng, Chai, High Seng, Younkin, Curtis, Crook, Julia E, Pankratz, V Shane, Carrasquillo, Minerva M, Krishnan, Siddharth, Nguyen, Thuy, Ma, Li, Malphrus, Kimberly, Lincoln, Sarah, Bisceglio, Gina, Kolbert, Christopher P, Jen, Jin, Mukherjee, Shubhabrata, Kauwe, John K, Crane, Paul K, Haines, Jonathan L, Mayeux, Richard, Pericak-Vance, Margaret A, Farrer, Lindsay A, Schellenberg, Gerard D, Parisi, Joseph E, Petersen, Ronald C, Graff-Radford, Neill R, Dickson, Dennis W, Younkin, Steven G, Ertekin-Taner, Nilüfer
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2014
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198935/
https://ncbi.nlm.nih.gov/pubmed/25324900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/alzrt268
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