Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levels

INTRODUCTION: MAPT encodes for tau, the predominant component of neurofibrillary tangles that are neuropathological hallmarks of Alzheimer’s disease (AD). Genetic association of MAPT variants with late-onset AD (LOAD) risk has been inconsistent, although insufficient power and incomplete assessment...

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Auteurs principaux: Allen, Mariet, Kachadoorian, Michaela, Quicksall, Zachary, Zou, Fanggeng, Chai, High Seng, Younkin, Curtis, Crook, Julia E, Pankratz, V Shane, Carrasquillo, Minerva M, Krishnan, Siddharth, Nguyen, Thuy, Ma, Li, Malphrus, Kimberly, Lincoln, Sarah, Bisceglio, Gina, Kolbert, Christopher P, Jen, Jin, Mukherjee, Shubhabrata, Kauwe, John K, Crane, Paul K, Haines, Jonathan L, Mayeux, Richard, Pericak-Vance, Margaret A, Farrer, Lindsay A, Schellenberg, Gerard D, Parisi, Joseph E, Petersen, Ronald C, Graff-Radford, Neill R, Dickson, Dennis W, Younkin, Steven G, Ertekin-Taner, Nilüfer
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2014
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198935/
https://ncbi.nlm.nih.gov/pubmed/25324900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/alzrt268
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