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THE ALZHEIMER'S AMYLOID β–PEPTIDE (Aβ) BINDS A SPECIFIC DNA Aβ–INTERACTING DOMAIN (AβID) IN THE APP, BACE1, AND APOE PROMOTERS IN A SEQUENCE–SPECIFIC MANNER: CHARACTERIZING A NEW REGULATORY MOTIF
Deposition of extracellular plaques, consisting of amyloid β peptide (Aβ), in the brain is the confirmatory diagnostic of Alzheimer’s disease (AD); however, the physiological and pathological role of Aβ is not fully understood. Herein, we demonstrate novel Aβ activity as a putative transcription fac...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3381326/ https://ncbi.nlm.nih.gov/pubmed/21699964 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2011.06.004 |
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