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THE ALZHEIMER'S AMYLOID β–PEPTIDE (Aβ) BINDS A SPECIFIC DNA Aβ–INTERACTING DOMAIN (AβID) IN THE APP, BACE1, AND APOE PROMOTERS IN A SEQUENCE–SPECIFIC MANNER: CHARACTERIZING A NEW REGULATORY MOTIF

Deposition of extracellular plaques, consisting of amyloid β peptide (Aβ), in the brain is the confirmatory diagnostic of Alzheimer’s disease (AD); however, the physiological and pathological role of Aβ is not fully understood. Herein, we demonstrate novel Aβ activity as a putative transcription fac...

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Bibliografische gegevens
Hoofdauteurs: Maloney, Bryan, Lahiri, Debomoy K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381326/
https://ncbi.nlm.nih.gov/pubmed/21699964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2011.06.004
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