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FUNCTIONAL ACTIVITY OF THE NOVEL ALZHEIMER’S AMYLOID β–PEPTIDE INTERACTING DOMAIN (AβID) IN THE APP AND BACE1 PROMOTER SEQUENCES AND IMPLICATIONS IN ACTIVATING APOPTOTIC GENES AND IN AMYLOIDOGENESIS
Amyloid β peptide (Aβ) plaque in the brain is the primary (post mortem) diagnostic criterion of Alzheimer’s disease (AD). Any physiological role of Aβ constituent is poorly understood. We have previously determined an Aβ interacting domain (AβID) in the promoters of AD–associated genes (Maloney and...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3372404/ https://ncbi.nlm.nih.gov/pubmed/21708232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2011.06.017 |
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