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Activation of Wnt/β-Catenin Protein Signaling Induces Mitochondria-mediated Apoptosis in Hematopoietic Progenitor Cells

The canonical Wnt/β-catenin signaling is activated during development, tumorigenesis, and in adult homeostasis, yet its role in maintenance of hematopoietic stem/progenitor cells is not firmly established. Here, we demonstrate that conditional expression of an active form of β-catenin in vivo induce...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ming, Ming, Wang, Sheng, Wu, Wenshu, Senyuk, Vitalyi, Le Beau, Michelle M., Nucifora, Giuseppina, Qian, Zhijian
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391123/
https://ncbi.nlm.nih.gov/pubmed/22589536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.342089
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