Oncogenic Kras Expression in Postmitotic Neurons Leads to S100A8-S100A9 Protein Overexpression and Gliosis

Previous studies suggest that up-regulation of Ras signaling in neurons promotes gliosis and astrocytoma formation in a cell nonautonomous manner. However, the underlying mechanisms remain unknown. To address this question, we generated compound mice (LSL Kras G12D/+;CamKII-Cre) that express oncogen...

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Detalhes bibliográficos
Main Authors: Ryu, Myung-Jeom, Liu, Yangang, Zhong, Xiaofen, Du, Juan, Peterson, Nicholas, Kong, Guangyao, Li, Hongda, Wang, Jinyong, Salamat, Shahriar, Chang, Qiang, Zhang, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391097/
https://ncbi.nlm.nih.gov/pubmed/22577135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.357772
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