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De Novo DNA Methylation Is Required to Restrict T Helper Lineage Plasticity
Naïve CD4+ T cells are highly plastic and can differentiate into discrete lineages with unique functions during an immune response. Once differentiated, helper T cells maintain a stable transcriptional memory of their initial lineage choice and resist redifferentiation. During embryogenesis, de novo...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3391093/ https://ncbi.nlm.nih.gov/pubmed/22584578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.312785 |
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