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De Novo DNA Methylation Is Required to Restrict T Helper Lineage Plasticity

Naïve CD4+ T cells are highly plastic and can differentiate into discrete lineages with unique functions during an immune response. Once differentiated, helper T cells maintain a stable transcriptional memory of their initial lineage choice and resist redifferentiation. During embryogenesis, de novo...

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Hlavní autoři: Thomas, Rajan M., Gamper, Christopher J., Ladle, Brian H., Powell, Jonathan D., Wells, Andrew D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391093/
https://ncbi.nlm.nih.gov/pubmed/22584578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.312785
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