De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8(+) T-cell fate decisions following activation

DNMT3a is a de novo DNA methyltransferase expressed robustly after T-cell activation that regulates plasticity of CD4(+) T-cell cytokine expression. Here we show that DNMT3a is critical for directing early CD8(+) T-cell effector and memory fate decisions. Whereas effector function of DNMT3a knockout...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Ladle, Brian H., Li, Kun-Po, Phillips, Maggie J., Pucsek, Alexandra B., Haile, Azeb, Powell, Jonathan D., Jaffee, Elizabeth M., Hildeman, David A., Gamper, Christopher J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035851/
https://ncbi.nlm.nih.gov/pubmed/27582468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524490113
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars