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De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8(+) T-cell fate decisions following activation
DNMT3a is a de novo DNA methyltransferase expressed robustly after T-cell activation that regulates plasticity of CD4(+) T-cell cytokine expression. Here we show that DNMT3a is critical for directing early CD8(+) T-cell effector and memory fate decisions. Whereas effector function of DNMT3a knockout...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5035851/ https://ncbi.nlm.nih.gov/pubmed/27582468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524490113 |
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