De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8(+) T-cell fate decisions following activation

DNMT3a is a de novo DNA methyltransferase expressed robustly after T-cell activation that regulates plasticity of CD4(+) T-cell cytokine expression. Here we show that DNMT3a is critical for directing early CD8(+) T-cell effector and memory fate decisions. Whereas effector function of DNMT3a knockout...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Ladle, Brian H., Li, Kun-Po, Phillips, Maggie J., Pucsek, Alexandra B., Haile, Azeb, Powell, Jonathan D., Jaffee, Elizabeth M., Hildeman, David A., Gamper, Christopher J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035851/
https://ncbi.nlm.nih.gov/pubmed/27582468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524490113
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