Inhibition of deoxyribonucleases by phosphorothioate groups in oligodeoxyribonucleotides.
The Rp- and Sp-diastereomers of the phosphorothioate-containing oligonucleotide d[ApAp(S)ApA] have been synthesized. They and the tetramer d[ApApApA] were tested as substrates for staphylococcal nuclease, DNase II and spleen phosphodiesterase. For digestions with DNase I these oligonucleotides were...
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| Veröffentlicht in: | Nucleic Acids Res |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
1988
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| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC339104/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2850541/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/16.24.11691 |
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