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Inhibition of deoxyribonucleases by phosphorothioate groups in oligodeoxyribonucleotides.

The Rp- and Sp-diastereomers of the phosphorothioate-containing oligonucleotide d[ApAp(S)ApA] have been synthesized. They and the tetramer d[ApApApA] were tested as substrates for staphylococcal nuclease, DNase II and spleen phosphodiesterase. For digestions with DNase I these oligonucleotides were...

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Bibliografiset tiedot
Julkaisussa:Nucleic Acids Res
Päätekijät: Spitzer, S, Eckstein, F
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 1988
Linkit:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC339104/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2850541/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/16.24.11691
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