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Inhibition of deoxyribonucleases by phosphorothioate groups in oligodeoxyribonucleotides.
The Rp- and Sp-diastereomers of the phosphorothioate-containing oligonucleotide d[ApAp(S)ApA] have been synthesized. They and the tetramer d[ApApApA] were tested as substrates for staphylococcal nuclease, DNase II and spleen phosphodiesterase. For digestions with DNase I these oligonucleotides were...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
1988
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC339104/ https://ncbi.nlm.nih.gov/pubmed/2850541 |
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